The incidence rate of chronic kidney failure in Indonesia in 2013 was 2.0% per mil and in 2018 increased to 3.8% per mil (Riskesdas, 2018). This proves that this disease is increasing. One of the effects of decreased kidney function is anemia. This is related to kidney function which produces the erythropetin hormone which functions to stimulate the bone marrow to form red blood cells. The purpose of this study was to analyze the relationship between anemia prevalence and chronic kidney failure in Drajat Prawiranegara District Hospital in Serang with a sample of 148 respondents. The design used in this study was cross sectional using secondary data, namely the patient's medical record. The results of this study are the patient's average hemoglobin level is 8.65 g/dl and the glomerular filtration rate of the patient is 10.95 ml/min/1.73 m2, with stage 3 patients with chronic kidney failure 8.1%, Stage 4 chronic kidney failure 18.2% and stage 5 chronic kidney failure 73.7%. From the One Way Anova test results found there was no difference in the Hemoglobin value with the stage in chronic kidney failure with a P value of 0.324. This can be an early detection of the risk of anemia in the early stages of chronic kidney disease.