Growth is a complex manifestation of morphological, biochemical, and physiological changes that occur from conception to maturity or adulthood. Knowledge and awareness of the parents and the cadres and the community in general is very necessary, in carrying out the monitoring of the development of children aged under five years. The purpose of this study is to know The Determinant Factors of the growth and development of children under five years at RW 011 Pondok Pinang South Jakarta. Research method: This research uses analytic design method. The sample used amounted to 80 people by using data collection technique Purposive Sampling. The results of this study is parents who have a good level of knowledge with good child development according to the age are 14 people (17.5%), the sufficient level of knowledge with child development deviation are 36 people (45.0%), the less level of knowledge with good development of children according to the age is no one (0%), and the less level of knowledge with child development deviation are 19 people (23.8%). There is a correlation between the levels of parents’ knowledge about toddlers’ development with the levels of toddlers’ development (p value = 0,000). The conclusion of this study is the level of knowledge enough with the development of good children according to age as much as 5 respondents 6.2% level of knowledge enough with the deviation on the development of children as much as 36 respondents 45.0%.