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Children Tuberculosis is an infection caused by Mycobacterium tuberculosis in children≤15 years old. Tuberculosis is spread by droplets. Inhaled MTb will trigger immune response and trigger cytokines production. The use of anti tuberculosis drug can also cause changes. This research was conducted to discover the relation between changes in hematological profile and nutritional status pre and post intensive phase treatment.  This study used a cross sectional method conducted in 62 samples in RSUP Persahabatan. Sampling method done by total sampling and medical record was used as instrument. This research was conducted in newly diagnosed TB patients with complete laboratory examination data including hemoglobin, erythrocytes, leukocyte, thrombocyte, and nutritional status pre and post intensive phase treatment carried out in 2017-2018. Exclusion criteria were patients with inflammatory diseases, such as HIV/AIDS, pneumonia and extrapulmonary TB patients. The results showed that the changes level in hemoglobin, erythrocytes, leukocyte, thrombocyte, and nutritional status showed that there was significant correlation between changes in HB (p=0,00), erythrocytes(p=0,030), leukocyte(p=0,042), thrombocyte(p=0,042), and nutritional status(p=0,007) with intensive phase treatment. Changes in leukocyte count marked as the most significant factor (25,157 times) in recovery of pediatric TB treatment. This study shown that intensive phase treatment parallel to improvement of hematological profile and nutritional status.