The problem of infection in nursing services in hospital and in health care facilities is that Healthcare-associated infections (HAIs) are still high. The compliance rate in implementing Infection Prevention and Control (IPC) is still low. Nurses' non-compliance with IPC implementation can be found in the ward with a variety of causative factors. This study aims to analyze the factors associated with nurse compliance in implementing infection prevention and control in hospital. The method used was quantitative research with cross sectional design. The respondents consisted of 34 implementing nurses at hospital X in Jakarta. The results showed a significant relationship between nurses 'knowledge (pv 0.01; α 0.05), motivation, (pv 0.04; α 0.05) and nurses' perceptions (pv 0.02; α 0.05) on adherence IPC implementation, but there is no relationship between attitude factor with the implementation of IPC (pv 0.51; α 0.05). Recommendations are expected to support nursing management, the head of room and service providers to improve nurses' compliance with the implementation of IPC as a basis for improving the quality of nursing services in hospitals through increasing the knowledge, motivation and perceptions of nurses in the provision of facilities and infrastructure in infection prevention and control.