Background: If the number of tasks is not proportional to the ability of both physical and expertise and the time available then it will be a source of stress. This study was conducted to through systematic review which analyzes the stress factors in nurses in hospitals intensive care unit (ICU).

Subjects and Methods: The data came from secondary data derived from literatures from 4 database sources, namely Elsevier, Proquest, Summon UI and Wiley Online Library. Search using keywords nurse staff AND stress factor AND intensive care unit AND hospital AND Asia as well as contributions to the literature which is the subject of this research are nurses, articles in English and full text, published from September 2009 to September 2019, in the Asia region and open access.

Results: The search process and filtering literature produced 6 (six) complete articles.

The articles found showed that internal and external factors is the main causes of stress among nurses, the nurses who experienced Post Traumatic Stress Disorder (PTSD) such as facing death and nurses working in ICU have more stress than nurses who work at other unit.

Conclusion: The stress factor on nurses in the hospital's ICU can be divided into Internal and External, in the internal sense that is from within the nurse's personal and external originating from the hospital's environment or management. It’s suggested that new nurse should not be pointed at ICU.

Keywords: stress factor; nurse; intensive care unit; coping.