In 2014, TB killed 1.5 million people, Indonesia occupies the second largest position of TB cases after India 23% which is equal to 10%. The high failure of the treatment program is also caused by the lack of support and motivation from the family while the patient is undergoing treatment. The impact is the patient becomes longer undergoing the program, the risk of transmission is greater, drug resistant. The purpose of this research is to determine the relationship between the role of the family as a Drug Supervisor with the level of compliance of pulmonary TB patients with treatment programs in the Serpong Community Health Center, South Tangerang. This research uses analytical descriptive design with cross sectional approach, the number of samples totaling 120 people, sampling using Total Sampling and data collection using questionnaires and interviews. The results of this research is the relationship between the role of the family as the supervisor of taking medication with the level of compliance of pulmonary TB patients to the treatment program in the area of ​​Serpong Community Health Center, South Tangerang (p = 0.001) Ha was received. The conclusion there is a relationship between the role of the family as a supervisor taking medication with the level of compliance of pulmonary TB patients with treatment programs in the area of ​​Serpong Community Health Center, South Tangerang.