Employee career development system is very crucial for each individual employee, because many things that affect employee career development include: Work Achievement, Exposure, Network work, Advisors and Sponsors, Opportunities for Growth, Employee and organizational relations, Politicking in Organizations, Award Systems , Organizational Culture. The purpose of this study, the authors want to find out the description of nurse career development, the relationship of career development factors with career development of nurses and the dominant factors that influence the development of career paths of nurses in the inpatient care unit at Pasar Minggu RSUD South Jakarta. This study uses a design with a cross sectional approach. The study was conducted from April to June 2019, with a sample of 116 nurses, with a purposive sampling technique. Data analysis using Spearman Correlation Test, Mann Whitney Test and multiple linear regression. The results showed that the most dominant factor in the development of inpatient careers at Pasar Minggu Public Hospital was Politicking in Organizations with beta values ​​of 0.453 and p value of 0.000. The conclusion of this study is that there is a significant effect of career development factors on the process of developing nurses' career paths in the inpatient room at Pasar Minggu Hospital (p value 0,000 and CI 95%). Suggestions for Pasar Minggu Hospital in order to make flexible policies to facilitate nurses to develop career paths.