Obesity is a risk factor for hepatocellular carcinoma (HCC), an experimental state of HCC can quickly be created by induction of  2-Nitropropane (2-NP). This causes an increase in reactive oxygen species (ROS) in the body. MnSOD is a first-line antioxidant that works by catalyzing the breakdown of two superoxide anion molecules (O₂^-) to hydrogen peroxide (H₂O₂) and oxygen molecules (O₂), changing superoxide anions which initially had dangerous potential to become less dangerous. Moringa leaves are rich in polyflavonoids and polyphenols which are potent antioxidant and anticancer compounds. This study aimed to analyze the effect of Moringa leaves extract and infusion on MnSOD levels of obesity mice's liver induced by 2-NP. In the analysis of liver MnSOD levels after treatment, there was a significant decrease in MnSOD levels in mice's liver (p<0.05). MnSOD levels in the 2-NP induced group is higher than the group given Moringa leaves extract and infusion because MnSOD in this group has experienced an upregulation mechanism as a sign of abnormal cell growth, whereas in the group given Moringa leaves extract and infusion there is a slowing upregulation mechanism.