Obesity can cause low grade chronic inflammation which results in increased ROS, which can lead to hepatocellular cancer. In several studies, it was proven that in the mice liver DNA  induced with 2-Nitropropane, showed an increase in reactive oxygen in the liver and was able to cause DNA damage. Oxidative stress damage can be prevented by endogenous antioxidant compounds, one of them is GSH. Antioxidants can also be obtained exogenously from Moringa leaves which contain quercetin flavonoids which can act as hepatoprotective agents. This research method uses obesity mice given extract (4 mg / kg) and leaf infusion (40 mg / kg) Moringa leaves for 20 days, then induced 2-Nitropropane (0.02 mL / kg). The results showed a decrease in liver GSH levels after 2-Nitropropane induction. The levels of GSH in the mice liver which given extracts and Moringa leaf infusion had differences with the control group. The conclusion of this study, there is an effect of Moringa leaf extract and infusion administration on GSH levels in the liver of obese mice induced by 2-Nitropropane.