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Tuberculosis is an infectious disease with a large number of cases in Indonesia and the World. Recoveries of tuberculosis are affected by multiple factors, such as medication adherence and smoking. Smoking will interfere with the immunity process to fight tuberculosis bacteria and affect hematologic level, for example in three chronic inflammatory parameters, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and erythrocyte sedimentation rate, and known to be the predictor for several chronic inflammatory diseases. The purpose of this study was to determine the relationship of pretreatment neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and erythrocyte sedimentation rate that recovery the new cases pulmonary tuberculosis (PTB) patients in adult smokers. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and erythrocyte sedimentation rate, and recoveries data are found in medical records. This research design study is cross-sectional with a sample size of 117 patients who meet the inclusion criteria. The results showed that there was a significant correlation between neutrophil-lymphocyte ratio (p=0,000), platelet-lymphocyte ratio (p=0,005), and erythrocyte sedimentation rate (p=0,044) with the recovery of new cases PTB patients in adult smokers. Increasing neutrophil-lymphocyte ratio is the most influential factor (6,632 times) that increase recovery failure for adult smokers patients with new case of PTB. In tuberculosis, there is an increase in neutrophil and platelet because of inflammatory mediator response and inhibition of apoptosis, decrease of lymphocyte because of promotion of apoptosis, and increase in erythrocyte sedimentation rate because of acute phase protein that can make bonds and increase in sedimentation.